Gigantizem: razlika med redakcijama

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'''Gigantizem''' ali '''giantizem''' ({{lang-el|γίγας}}, ''gígas'', "[[velikan]]", množina γίγαντες, ''gígantes'') je bolezensko stanje, pri katerem je za obolelega značilna pretirana rast in telesna višina, ki presega povprečne vrednosti. Pri ljudeh do gigantizma pride zaradi pretiranega nastajanja [[Rastni hormon|rastnega hormona]] (somatotropina<ref>{{Navedi splet|title=Termania - Slovenski medicinski slovar - somatotropín|url=https://www.termania.net/slovarji/slovenski-medicinski-slovar/5539149/somatotropin?ld=95&query=rastni+hormon&SearchIn=Linked|website=www.termania.net|accessdate=2021-06-19}}</ref>)<ref>{{DorlandsDict|four/000044375|Gigantism}}</ref> v obdobju otroštva, pri čemer tovrstni ljudje dosežejo telesne višine od 2,1 do 2,7 metrov.<ref>{{Cite web|url=http://pituitary.ucla.edu/resources|title=Gigantism {{!}} UCLA Pituitary Tumor Program|website=pituitary.ucla.edu|access-date=2017-04-27}}</ref><ref>{{Cite web|url=https://medlineplus.gov/ency/article/001174.htm|title=Gigantism: MedlinePlus Medical Encyclopedia|website=medlineplus.gov|language=en|access-date=2017-04-27}}</ref><ref>{{Cite journal|date=2017-01-07|title=Gigantism and Acromegaly: Practice Essentials, Background, Pathophysiology and Etiology|url=http://emedicine.medscape.com/article/925446-overview}}</ref><ref>{{Cite news|url=https://www.msdmanuals.com/home/hormonal-and-metabolic-disorders/pituitary-gland-disorders/gigantism-and-acromegaly|title=Gigantism and Acromegaly - Hormonal and Metabolic Disorders - MSD Manual Consumer Version|work=MSD Manual Consumer Version|access-date=2017-04-27|language=en}}</ref>
 
Gre za razmeroma redko bolezensko motnjo, ki je posledica zvišanih ravni rastnega hormona v obdobju pred zlitjem rastnega ([[Epifizni hrustanec|epifiznega]]) [[Hrustančevina|hrustanca]]. Stanje se običajno pojavi zaradi nenormalnih izrastlin ([[Tumor|tumorjev]]) na [[Hipofiza|hipofizi]].<ref name=":0">{{Cite journal|last1=Rostomyan|first1=Liliya|last2=Daly|first2=Adrian F.|last3=Petrossians|first3=Patrick|last4=Nachev|first4=Emil|last5=Lila|first5=Anurag R.|last6=Lecoq|first6=Anne-Lise|last7=Lecumberri|first7=Beatriz|last8=Trivellin|first8=Giampaolo|last9=Salvatori|first9=Roberto|date=October 2015|title=Clinical and genetic characterization of pituitary gigantism: an international collaborative study in 208 patients|journal=Endocrine-Related Cancer|volume=22|issue=5|pages=745–757|doi=10.1530/ERC-15-0320|issn=1479-6821|pmid=26187128|pmc=6533620}}</ref><ref name=":1">{{Cite journal|last1=Rostomyan|first1=Liliya|last2=Potorac|first2=Iulia|last3=Beckers|first3=Pablo|last4=Daly|first4=Adrian F.|last5=Beckers|first5=Albert|title=AIP mutations and gigantism|journal=Annales d'Endocrinologie|volume=78|issue=2|pages=123–130|doi=10.1016/j.ando.2017.04.012|pmid=28483363|year=2017}}</ref> Gigantizma se ne sme zamenjevati z [[Akromegalija|akromegalijo]], ki je odrasla različica iste bolezenske motnje, in pri kateri se pojavi povečevanje [[Organ (biologija)|organov]] in akrov (štrlečih oziroma distalnih delov telesa).<ref>{{Cite journal|last1=Chanson|first1=Philippe|last2=Salenave|first2=Sylvie|date=2008-06-25|title=Acromegaly|journal=Orphanet Journal of Rare Diseases|volume=3|pages=17|doi=10.1186/1750-1172-3-17|pmid=18578866|pmc=2459162|issn=1750-1172}}</ref><ref>{{Cite journal|last1=Capatina|first1=Cristina|last2=Wass|first2=John A. H.|date=August 2015|title=60 YEARS OF NEUROENDOCRINOLOGY: Acromegaly|journal=The Journal of Endocrinology|volume=226|issue=2|pages=T141–160|doi=10.1530/JOE-15-0109|issn=1479-6805|pmid=26136383|doi-access=free}}</ref><ref>{{Navedi splet|title=Termania - Slovenski medicinski slovar - akromegalíja|url=https://www.termania.net/slovarji/slovenski-medicinski-slovar/5504847/akromegalija?ld=95&query=akromegalija&SearchIn=Linked|website=www.termania.net|accessdate=2021-06-19}}</ref><ref>{{Navedi knjigo|edition=[1st English ed.]|title=The human body : an introduction to structure and function|url=https://www.worldcat.org/oclc/56415097|publisher=Georg Thieme|date=2004|location=Stuttgart|isbn=978-3-13-129271-1|oclc=56415097|first=Adolf|last=Faller|first2=Gabriele|last2=Schünke|first3=Ethan|last3=Taub}}</ref>