SARS-CoV-2: Razlika med redakcijama
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Tako kot SARS-u soroden sev, odgovoren za izbruh SAR 2003, je tudi SARS-CoV-2 član ''podvrste Sarbecovirus'' ( beta-CoV sev B).<ref name="Hui14Jan2020">{{Navedi revijo|title=The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health – The latest 2019 novel coronavirus outbreak in Wuhan, China|journal=International Journal of Infectious Diseases|volume=91|pages=264–266|date=February 2020|pmid=31953166|doi=10.1016/j.ijid.2020.01.009|display-authors=6}} {{Prosti dostop}}</ref><ref>{{Navedi splet|url=https://nextstrain.org/groups/blab/sars-like-cov|title=Phylogeny of SARS-like betacoronaviruses|website=nextstrain|accessdate=18 January 2020|archiveurl=https://web.archive.org/web/20200120190511/https://nextstrain.org/groups/blab/sars-like-cov|archivedate=20 January 2020}}</ref><ref name="Wong2019">{{Navedi revijo|title=Global Epidemiology of Bat Coronaviruses|journal=Viruses|volume=11|issue=2|pages=174|date=February 2019|pmid=30791586|pmc=6409556|doi=10.3390/v11020174}}</ref> Njegova sekvenca [[Ribonukleinska kislina|RNA]] je dolga približno 30 000 baz .<ref name=":gisaid">{{Navedi splet|url=https://platform.gisaid.org/epi3/start/CoV2020|title=CoV2020|website=GISAID EpifluDB|accessdate=12 January 2020|archiveurl=https://web.archive.org/web/20200112130540/https://platform.gisaid.org/epi3/start/CoV2020|archivedate=12 January 2020}}</ref> SARS-CoV-2 je edinstven med znanimi betakoronavirusi po tem, da vključuje mesto za večbazno cepitev, kar ki povečuje [[Patogen|patogenost]] in prenosljivost pri drugih virusih.<ref name="Proximal">{{Navedi revijo|title=Correspondence: The proximal origin of SARS-CoV-2|url=https://www.nature.com/articles/s41591-020-0820-9|display-authors=6|date=17 March 2020|journal=[[Nature Medicine]]|pages=1–3|doi=10.1038/s41591-020-0820-9|accessdate=18 March 2020|archiveurl=https://web.archive.org/web/20200318001738/https://www.nature.com/articles/s41591-020-0820-9|archivedate=18 March 2020}}</ref><ref>{{Navedi revijo|title=Structure, function and antigenicity of the SARS-CoV-2 spike glycoprotein|display-authors=6|date=9 March 2020|journal=[[Cell (journal)|Cell]]|doi=10.1016/j.cell.2020.02.058|pmid=32155444}}</ref><ref>{{Navedi revijo|title=The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade|journal=Antiviral Research|volume=176|pages=104742|date=February 2020|pmid=32057769|doi=10.1016/j.antiviral.2020.104742|display-authors=6}}</ref>
Analiza sekvenc genomov v javno dostopnih vzorcih SARS-CoV-2 in pri sorodnih virusov ni našla nobenih dokazov, da bi virus bil ustvarjen ne z evolucijo, temveč v laboratoriju.<ref name=":3">Kristian G. Andersen, Andrew Rambaut, W. Ian Lipkin, Edward C. Holmes, Robert F. Garry. '''The proximal origin of SARS-CoV-2'''. ''Nature Medicine'', 2020; DOI: 10.1038/s41591-020-0820-9</ref> Da je virus ustvarila naravna evolucija, podpirajo podatki o hrbtenici SARS-CoV-2 in njeni celotni molekularni strukturi. Če bi kdo skušal oblikovati nov koronavirus kot patogen, bi za hrbtenico uporabil sktrukturo virusa, za katerega je znano, da povzroča bolezen. Znanstveniki pa nasprotno so ugotovili, da se hrbtenica SARS-CoV-2 bistveno razlikuje od hrbtenice že znanih koronavirusov in večinoma spominja na sorodne viruse, ki jih najdemo v netopirjih in luskavcih. "Ti dve značilnosti virusa, mutacije v RBD delu proteina konice in v njegovi samosvojski hrbtenici izključujejo laboratorijske manipulacije kot potencialni izvorSARS-CoV-2,"<ref name=":3" />.
Z zadostnim številom sekvenciranih [[Dednina|genomov]] je bilo mogoče rekonstruirati filogenetsko drevo in zgodovino mutacij v družini virusov. Do 12. januarja 2020 so Kitajski center za nadzor in preprečevanje bolezni (CCDC) in druge institucije iz Wuhana izolirale in objavile pet genomov SARS-CoV-2;<ref name=":gisaid">{{Navedi splet|url=https://platform.gisaid.org/epi3/start/CoV2020|title=CoV2020|website=GISAID EpifluDB|accessdate=12 January 2020|archiveurl=https://web.archive.org/web/20200112130540/https://platform.gisaid.org/epi3/start/CoV2020|archivedate=12 January 2020}}</ref><ref>{{Navedi splet|url=http://virological.org/t/initial-genome-release-of-novel-coronavirus/319|title=Initial genome release of novel coronavirus|date=11 January 2020|website=Virological|accessdate=12 January 2020|archiveurl=https://web.archive.org/web/20200112100227/http://virological.org/t/initial-genome-release-of-novel-coronavirus/319|archivedate=12 January 2020}}</ref> do 30. januarja 2020 je število genomov poraslo na 42.<ref name="NextstrainJanuary">{{Navedi splet|url=https://nextstrain.org/narratives/ncov/sit-rep/2020-01-30|title=Genomic analysis of nCoV spread: Situation report 2020-01-30|display-authors=6|website=nextstrain.org|accessdate=18 March 2020|archiveurl=https://web.archive.org/web/20200315182810/https://nextstrain.org/narratives/ncov/sit-rep/2020-01-30|archivedate=15 March 2020}}</ref> Filogenetska analiza teh vzorcev je pokazala, da so "tesno v sorodu, z največ sedmimi mutacijami oddaljeni od skupnega prednika ", kar pomeni, da je do prve okužbe pri ljudeh moralo priti novembra ali decembra 2019. 13. marca 2020 je bilo javno dostopnih že 410 genomov SARS-CoV-2, vzorčenih na petih celinah.<ref name="NextstrainMarch">{{Navedi splet|url=https://nextstrain.org/narratives/ncov/sit-rep/2020-03-13|title=Genomic analysis of COVID-19 spread: Situation report 2020-03-13|display-authors=6|website=nextstrain.org|accessdate=18 March 2020|archiveurl=https://web.archive.org/web/20200313225516/https://nextstrain.org/narratives/ncov/sit-rep/2020-03-13|archivedate=13 March 2020}}</ref>
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