Fibromialgija: Razlika med redakcijama

Ni še znano, na kak način se nagnjenost k fibromialgiji deduje, podatki pa kažejo, da je vpletenih več [[gen]]ov.<ref name="Buskila-2006"/> Raziskave so pokazale morebitno povezanost fibromialgije s [[polimorfizem|polimorfizmom]] genov, vpletenih v [[serotonin]]ski,<ref>{{cite journal |vauthors=Cohen H, Buskila D, Neumann L, Ebstein RP | title = Confirmation of an association between fibromyalgia and serotonin transporter promoter region (5- HTTLPR) polymorphism, and relationship to anxiety-related personality traits | journal = Arthritis Rheum. | volume = 46 | issue = 3 | pages = 845–847 | date = marec 2002 | pmid = 11920428 | doi = 10.1002/art.10103 }}</ref> [[dopamin]]ergični<ref>{{cite journal |vauthors=Buskila D, Dan B, Cohen H, Hagit C, Neumann L, Lily N, Ebstein RP | title = An association between fibromyalgia and the dopamine D4 receptor exon III repeat polymorphism and relationship to novelty seeking personality traits | journal = Mol. Psychiatry | volume = 9 | issue = 8 | pages = 730–731 | date = avgust 2004 | pmid = 15052273 | doi = 10.1038/sj.mp.4001506 }}</ref> in [[kateholamin]]ergični sistem.<ref>{{cite journal |vauthors=Zubieta JK, Heitzeg MM, Smith YR, Bueller JA, Xu K, Xu Y, Koeppe RA, Stohler CS, Goldman D | title = COMT val158met genotype affects mu-opioid neurotransmitter responses to a pain stressor | journal = Science | volume = 299 | issue = 5610 | pages = 1240–1243 | date = februar 2003 | pmid = 12595695 | doi = 10.1126/science.1078546 }}</ref> Omenjeni polimorfizmi niso specifični za fibromialgijo, temveč so povezani s številnimi drugimi sorodnimi boleznimi, kot sta [[sindrom kronične utrujenosti]]<ref>{{cite journal |vauthors=Narita M, Nishigami N, Narita N, Yamaguti K, Okado N, Watanabe Y, Kuratsune H | title = Association between serotonin transporter gene polymorphism and chronic fatigue syndrome | journal = Biochem. Biophys. Res. Commun. | volume = 311 | issue = 2 | pages = 264–266 | date = november 2003 | pmid = 14592408 | doi = 10.1016/j.bbrc.2003.09.207 }}</ref> in [[sindrom razdražljivega črevesja]]<ref>{{cite journal |vauthors=Camilleri M, Atanasova E, Carlson PJ, Ahmad U, Kim HJ, Viramontes BE, McKinzie S, Urrutia R | title = Serotonin-transporter polymorphism pharmacogenetics in diarrhea-predominant irritable bowel syndrome | journal = Gastroenterology | volume = 123 | issue = 2 | pages = 425–432 | date = avgust 2002 | pmid = 12145795 | doi = 10.1053/gast.2002.34780 }}</ref>), ter tudi z [[depresija|depresijo]].<ref>{{cite journal |vauthors=Hudson JI, Mangweth B, Pope HG, De Col C, Hausmann A, Gutweniger S, Laird NM, Biebl W, Tsuang MT | title = Family study of affective spectrum disorder | journal = Arch. Gen. Psychiatry | volume = 60 | issue = 2 | pages = 170–177 | date = februar 2003 | pmid = 12578434 | doi = 10.1001/archpsyc.60.2.170 }}</ref> Raziskave so pokazale, da so za fibromialgijo bolj dovzetni na primer posamezniki s polimorfizmom 102T/C receptorja [[5-HT2A]].<ref name="pmid21120487">{{cite journal |vauthors=Lee YH, Choi SJ, Ji JD, Song GG | title = Candidate gene studies of fibromyalgia: a systematic review and meta-analysis | journal = Rheumatol. Int. | volume = 32 | issue = 2 | pages = 417–426 | date = februar 2012 | pmid = 21120487 | doi = 10.1007/s00296-010-1678-9 | url = }}</ref>