Zaviralec proteaz: Razlika med redakcijama

* Kombinacija ritonavirja in lopinavirja je pokazala določeno stopnjo učinkovitosti proti [[giardioza|giardiozi]].<ref name="pmid17137752">{{cite journal |authorauthors=Dunn LA, Andrews KT, McCarthy JS,|display-authors= ''et al.'' |title=The activity of protease inhibitors against Giardia duodenalis and metronidazole-resistant Trichomonas vaginalis |journal=Int. J. Antimicrob. Agents |volume=29 |issue=1 |pages=98–102 |year=2007 |pmid=17137752 |doi=10.1016/j.ijantimicag.2006.08.026}}</ref>

* Sakvinavir, ritonavir in lopinavir izkazujejo učinkovitost proti malariji.<ref name="pmid16436721">{{cite journal |authorauthors=Andrews KT, Fairlie DP, Madala PK,|display-authors= ''et al.'' |title=Potencies of human immunodeficiency virus protease inhibitors in vitro against Plasmodium falciparum and in vivo against murine malaria |journal=Antimicrob. Agents Chemother. |volume=50 |issue=2 |pages=639–648 |year=2006 |pmid=16436721 |doi=10.1128/AAC.50.2.639-648.2006 |pmc=1366900}}</ref>

* Zaviralec [[serinska proteaza|serinske proteaze]] je v raziskavah na [[miš]]ih ozdravil [[Chagasova bolezen|Chagasovo bolezen]].<ref name="pmid17698625">{{cite journal |authorauthors=Doyle PS, Zhou YM, Engel JC, McKerrow JH |title=A Cysteine Protease Inhibitor Cures Chagas' Disease in an, Immunodeficient Murine Model of Infection |journal= Antimicrobial Agents and Chemotherapy|volume= 51|issue= 11|pages=3932|year=2007 |pmid=17698625 |doi=10.1128/AAC.00436-07 |pmc=2151429}}</ref>

Potekajo raziskave o ugotavljanju potencialne uporabe zaviralcev proteaz pri zdravljenju [[rak (bolezen)|raka]]. Na primer nelfinavir in atazanavir ubijeta rakave kulture v [[petrijevka]]h.<ref>{{cite journal|url=http://clincancerres.aacrjournals.org/cgi/content/abstract/13/17/5183|author= J.J. Gills|display-authors= et al. |title=Nelfinavir, A Lead HIV Protease Inhibitor, Is a Broad-Spectrum, Anticancer Agent that Induces Endoplasmic Reticulum Stress, Autophagy, and Apoptosis In vitro and In vivo|journal= Clinical Cancer Research |volume=13|pages=5183–94|year=2007 |doi=10.1158/1078-0432.CCR-07-0161 |pmid=17785575|issue=17}}</ref><ref name="Pyrko">{{cite journal|url= |title=HIV-1 protease inhibitors nelfinavir and atazanavir induce malignant glioma death by triggering endoplasmic reticulum stress|journal= Cancer Research |volume=67|pages=10920–8|year=2007 |doi=10.1158/0008-5472.CAN-07-0796 |author=Pyrko, P. |pmid=18006837|last2= Kardosh|first2= A|last3= Wang|first3= W|last4= Xiong|first4= W|last5= Schönthal|first5= AH|last6= Chen|first6= TC|issue= 22}}</ref> Učinek na ljudeh še ni bil raziskan, so pa raziskave na miših pokazale, da nelpinavir zavira rast tumorjev.<ref name="Pyrko"/>