Acetilsalicilna kislina: Razlika med redakcijama

[[Salicilna kislina]], glavni presnovek aspirina, je integralni del človeške in živalske presnove. Človek jo veliko zaužije s hrano, precejšen del pa se sintetizira [[endogenost|endogeno]].<ref name=Paterson_2008>{{navedi revijo | last1 = Paterson | first1 = John R. | last2 = Baxter | first2 = Gwendoline | last3 = Dreyer | first3 = Jacob S. | last4 = Halket | first4 = John M. | last5 = Flynn | first5 = Robert | last6 = Lawrence | first6 = James R. | doi = 10.1021/jf800974z | title = Salicylic Acid sans Aspirin in Animals and Man: Persistence in Fasting and Biosynthesis from Benzoic Acid | journal = Journal of Agricultural and Food Chemistry | volume = 56 | issue = 24 | pages = 11648–11652 | year = 2008 | pmid = 19053387 | pmc =2800778}}</ref>

 

| coauthors = J W Davis, D G Archibald, W E Steinke, T C Smitherman, J E Doherty, H W Schnaper, M M LeWinter, E Linares, J M Pouget, S C Sabharwal, E Chesler, H DeMots| title = Protective effects of aspirin against acute myocardial infarction and death in men with unstable angina. Results of a Veterans Administration Cooperative Study| journal = The New England Journal of Medicine| date = 18. avgusta 1983| pmid = 6135989}}</ref> V nizkih odmerkih se lahko aspirin uporabi takoj po srčnem infarktu za preprečitev ponovnega infarkta ali odmrtja srčnega tkiva.<ref name="anticoag">{{navedi revijo|last = Julian|first = D G|coauthors = D A Chamberlain, S J Pocock|title = A comparison of aspirin and anticoagulation following thrombolysis for myocardial infarction (the AFTER study): a multicentre unblinded randomised clinical trial|journal = BMJ| volume = 313|issue = 7070|pages = 1429–1431|publisher = British Medical Journal|date = 24. septembra 1996|pmid = 8973228|pmc = 2353012|doi = 10.1136/bmj.313.7070.1429}}</ref><ref>{{navedi revijo| volume = 92| issue = 10| pages = 2841–2847| last = Krumholz| first = Harlan M.| coauthors = Martha J. Radford, Edward F. Ellerbeck, John Hennen, Thomas P. Meehan, Marcia Petrillo, Yun Wang, Timothy F. Kresowik, Stephen F. Jencks| title = Aspirin in the Treatment of Acute Myocardial Infarction in Elderly Medicare Beneficiaries : Patterns of Use and Outcomes| journal = Circulation| year = 1995|pmid = 7586250| doi = 10.1161/01.CIR.92.10.2841}}</ref>

Aspirin lahko tudi učinkovito preprečuje nekatere vrste raka, zlasti [[kolorektalni rak]] (rak debelega črevesa in danke).<ref name="thelancet.com">{{cite journal|doi=10.1016/S1470-2045(12)70112-2|title=Effects of regular aspirin on long-term cancer incidence and metastasis: A systematic comparison of evidence from observational studies versus randomised trials|year=2012|last1=Algra|first1=Annemijn M|last2=Rothwell|first2=Peter M|journal=The Lancet Oncology|url=http://www.thelancet.com/journals/lanonc/article/PIIS1470-2045%2812%2970112-2/abstract|volume=13|issue=5|pages=518–27|pmid=22440112}}</ref><ref name="thelancet.com"/><ref>{{cite journal|doi=10.1016/S0140-6736(11)61720-0|title=Short-term effects of daily aspirin on cancer incidence, mortality, and non-vascular death: Analysis of the time course of risks and benefits in 51 randomised controlled trials|year=2012|last1=Rothwell|first1=Peter M|last2=Price|first2=Jacqueline F|last3=Fowkes|first3=F Gerald R|last4=Zanchetti|first4=Alberto|last5=Roncaglioni|first5=Maria Carla|last6=Tognoni|first6=Gianni|last7=Lee|first7=Robert|last8=Belch|first8=Jill FF|last9=Wilson|first9=Michelle|journal=The Lancet|volume=379|issue=9826|pages=1602}}</ref><ref>{{navedi revijo|doi=10.1016/S0140-6736(12)60209-8|title=Effect of daily aspirin on risk of cancer metastasis: A study of incident cancers during randomised controlled trials|year=2012|last1=Rothwell|first1=Peter M|last2=Wilson|first2=Michelle|last3=Price|first3=Jacqueline F|last4=Belch|first4=Jill FF|last5=Meade|first5=Tom W|last6=Mehta|first6=Ziyah|journal=The Lancet|volume=379|issue=9826|pages=1591}}</ref>