Acetilsalicilna kislina: Razlika med redakcijama

Aspirin lahko tudi učinkovito preprečuje nekatere vrste raka, zlasti [[kolorektalni rak]] (rak debelega črevesa in danke).<ref name="thelancet.com">{{cite journal|doi=10.1016/S1470-2045(12)70112-2|title=Effects of regular aspirin on long-term cancer incidence and metastasis: A systematic comparison of evidence from observational studies versus randomised trials|year=2012|last1=Algra|first1=Annemijn M|last2=Rothwell|first2=Peter M|journal=The Lancet Oncology|url=http://www.thelancet.com/journals/lanonc/article/PIIS1470-2045%2812%2970112-2/abstract|volume=13|issue=5|pages=518–27|pmid=22440112}}</ref><ref name="thelancet.com"/><ref>{{cite journal|doi=10.1016/S0140-6736(11)61720-0|title=Short-term effects of daily aspirin on cancer incidence, mortality, and non-vascular death: Analysis of the time course of risks and benefits in 51 randomised controlled trials|year=2012|last1=Rothwell|first1=Peter M|last2=Price|first2=Jacqueline F|last3=Fowkes|first3=F Gerald R|last4=Zanchetti|first4=Alberto|last5=Roncaglioni|first5=Maria Carla|last6=Tognoni|first6=Gianni|last7=Lee|first7=Robert|last8=Belch|first8=Jill FF|last9=Wilson|first9=Michelle|journal=The Lancet|volume=379|issue=9826|pages=1602}}</ref><ref>{{navedi revijo|doi=10.1016/S0140-6736(12)60209-8|title=Effect of daily aspirin on risk of cancer metastasis: A study of incident cancers during randomised controlled trials|year=2012|last1=Rothwell|first1=Peter M|last2=Wilson|first2=Michelle|last3=Price|first3=Jacqueline F|last4=Belch|first4=Jill FF|last5=Meade|first5=Tom W|last6=Mehta|first6=Ziyah|journal=The Lancet|volume=379|issue=9826|pages=1591}}</ref>

 

 

Aspirin spada v skupino zdravil, ki jih imenujemo [[nesteroidni antiflogistik]]i (nesteroidne protivnetne učinkovine; NSAID), vendar se po svojem mehanizmu delovanja razlikuje od preostalih učinkovin v tej skupini. Čeprav imajo vsi salicilati iz te skupine podobne učinke (antipiretične, antiflogistične, analgetične) in vsi zavirajo encim [[ciklooksigenaza|ciklooksigenazo]], v nasprotju s preostalimi salicilati aspirin učinkuje [[ireverzibilna inhibicija|ireverzibilno]] in bolj na različico COX-1 kot COX-2 tega encima.<ref name="Goodman and Gilman's">{{Cite book| last = Burke| first = Anne|last2=Smyth|first2=Emer|last3=FitzGerald|first3=Garret A. | chapter=26: Analgesic Antipyretic and Antiinflammatory Agents |title=Goodman and Gilman's the pharmacological basis of therapeutics| publisher = McGraw-Hill| year = 2006 |edition=11 |isbn=978-0-07-142280-2 |location = New York| pages = 671–716|url=http://www.accessmedicine.com/content.aspx?aID=942410&searchStr=aspirin }}</ref>